Antihyperglycemic effects of stevioside on diabetic rats
Ashoush I.S.; Jehan, A. El-Shourbagy;
Abstract
Stevioside as a natural sweetener was extracted from leaves of plant Stevia rebaudiana Bertoni, and evaluated in alloxan-induced diabetes in rats. Results showed that oral administration of 500 mg kg-1 body weight of the stevioside for successive three weeks produced, significant reduction in blood glucose in diabetic rats. These results were compared with glibenclamide (600 μg/kg, orally) as a standard antihyperglycaemic agent. Also, a deformation of pancreatic b-cells was observed in the diabetic rats treated with stevioside. This indicates that stevioside may be a promising antidiabetic agent in treatment of type 2 diabetes. Stevioside was proved to be a potential drug or food additive for improving diabetes regulation.
Other data
| Title | Antihyperglycemic effects of stevioside on diabetic rats | Authors | Ashoush I.S. ; Jehan, A. El-Shourbagy | Issue Date | 1-Dec-2008 | Publisher | IBGE, University of Sindh, Jamshoro, Pakistan | Journal | Pakistan Journal of Biotechnology, 5(1-2):21-26 | DOI | https://api.elsevier.com/content/abstract/scopus_id/77953469200 | Scopus ID | 2-s2.0-77953469200 |
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