Self-assembled amphiphilic core-shell nanocarriers in line with the modern strategies for brain delivery

Elezaby, Reham ; Gad H. ; Metwally A. ; Geneidi A. ; Awad G. 


Abstract


© 2017 Elsevier B.V. Disorders of the central nervous system (CNS) represent increasing social and economic problems all over the world which makes the effective transport of drugs to the brain a crucial need. In the last decade, many strategies were introduced to deliver drugs to the brain trying to overcome the challenge of the blood brain barrier (BBB) using both invasive and non-invasive methods. Non-invasive strategy represented in the application of nanocarriers became very common. One of the most hopeful nanoscopic carriers for brain delivery is core-shell nanocarriers or polymeric micelles (PMs). They are more advantageous than other nanocarriers. They offer small size, ease of preparation, ease of sterilization and the possibility of surface modification with various ligands. Hence, the aim of this review is to discuss modern strategies for brain delivery, micelles as a successful delivery system for the brain and how micelles could be modified to act as “magic bullets” for brain delivery.


Other data

Keywords nanoparticles, micelles, brain delivery
Issue Date 10-Sep-2017
Journal Journal of Controlled Release 
Description the review article discussed the modern strategies for brain delivery and the application of polymeric micelles as promising nano-carriers in this field
URI http://research.asu.edu.eg/handle/123456789/167108
DOI 43
https://api.elsevier.com/content/abstract/scopus_id/85021217216
261
1873-4995
10.1016/j.jconrel.2017.06.019


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