Synthesis and anticancer activity of novel quinazolinone and benzamide derivatives
El-Hashash M.; M. S. Salem; Al-Mabrook S.;
Abstract
© 2018, Springer Science+Business Media B.V., part of Springer Nature. In trying to develop new anticancer agents, a series of quinazolinone and benzamide derivatives were synthesized via reaction of 6-iodo-2-phenyl-4H-benzoxazin-4-one with nitrogen nucleophiles, namely, formamide, ammonium acetate, hydrazine hydrate, hydroxylamine hydrochloride, substituted aromatic amines, benzyl amine, and/or thiocarbonohydrazide. All compounds were fully characterized by means of IR, MS, and1H-NMR spectra. Some of the synthesized compounds were evaluated in vitro for their anti-proliferative activity against HePG-2 and MCF-7 cell lines. 2-(Benzoylamino)-N-(4-hydroxyphenyl)-5-iodobenzamide and tetrazino[1,6-c]quinazoline-3(4H)-thione derivative were the most potent against the two cancer cells comparable to that of doxorubicin. Most of the synthesized compounds also exhibited good cytotoxic activity.
Other data
Title | Synthesis and anticancer activity of novel quinazolinone and benzamide derivatives | Authors | El-Hashash M. ; M. S. Salem ; Al-Mabrook S. | Issue Date | 1-Apr-2018 | Journal | Research on Chemical Intermediates | DOI | 4 https://api.elsevier.com/content/abstract/scopus_id/85040792502 2545 44 10.1007/s11164-017-3245-4 |
Scopus ID | 2-s2.0-85040792502 |
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