VANADIUM AS AN ANTIOXIDANT AND DIABETES MELLITUS IN ADULT MALE ALBINO RATS

Abstract

Diabetes mellitus (DM) is characterised by hyperglycaemia that is often associated with long-term complications, including retinopathy, nephropathy, and neuropathy, macro vascular and micro vascular damage. The present study was designed to evaluate the ability of sodium orthovanadate (SOV) to ameliorate the disturbances in some physiological parameters induced by DM in rats. Histological studied on the pancreas were also involved. Serum glucose, glycosylated haemoglobin HbA1c, lipid profiles and lipid peroxidation levels were significantly elevated in diabetic rats injected with STZ, whereas, the levels of C-peptide and liver glycogen content were significantly decreased. Some histopathological lesions were also observed. The administration of SOV at low doses (50 mg/kg daily) to diabetic rats improved the previous parameters. However, this amelioration did not occur with the high dose (100 mg/kg daily).