Antimicrobial resistance pattern of some bacterial pathogens involved in lower respiratory tract infections in Egypt
Aboshanab K. M.; Abdelaziz, Salma; Hassouna, Nadia A; Aboulwafa, Mohammad M;
Abstract
Background: Resistance of bacteria to the used antimicrobials has risen
dramatically in the past years. Special attention has to be given to
infections caused by multiple drug resistant (MDR) organisms, as the
therapeutic options are usually limited. The aim of this study is to determine
the susceptibility and resistance prevalence bacteria isolated
from patients suffering from lower respiratory tract infections (LRTI)
against different antimicrobials commonly used in Egypt.
Methods and findings: A total of 235 bacterial isolates were recovered
from sputum and bronchoalveolar lavage specimens obtained from
patients with LRTI. The specimens were collected during the period
from January 2012 to December 2012 from the microbiological diagnostic
laboratory of Sadr Al-Abbassiya hospital specialized in the treatment
of chest infections in Cairo, Egypt. The antimicrobial susceptibility
testing showed that the lowest resistance was observed to amikacin,
doxycycline and meropenem; only 19 isolates (8%) were resistant
to each. While the highest resistance was observed to clindamycin;
108 isolates (45.9%) were resistant. Among the collected isolates; 62
isolates (26.4%) were found to be resistant to 6 or more antimicrobial
agents; 53 isolates were Gram-negative (85.5%) while 9 isolates
were Gram-positive (14.5%). Out of these 62 MDR isolates; 23 isolates
were Klebsiella pneumoniae (37.1%), 15 isolates were Escherichia
coli (24.2%), 10 isolates were Pseudomonas aeruginosa (16.1%), 9
isolates were Staphylococcus aureus (14.5%), 3 isolates were Enterobacter
cloacae (4.8%) and 2 isolates were Acinetobacter baumannii
(3.2%). Most MDR organisms showed resistance to tested penicillin
derivatives, cephalosporins as well as co-trimoxazole and macrolide
antibiotics, with the exception of azithromycin . Conclusion: Multiple drug resistance is a major health concern limiting
the use of common antimicrobials in therapy. Guided prescription of
antimicrobial agents must be implemented and controlled in Egyptian
hospitals to limit further spread of antimicrobial resistance
dramatically in the past years. Special attention has to be given to
infections caused by multiple drug resistant (MDR) organisms, as the
therapeutic options are usually limited. The aim of this study is to determine
the susceptibility and resistance prevalence bacteria isolated
from patients suffering from lower respiratory tract infections (LRTI)
against different antimicrobials commonly used in Egypt.
Methods and findings: A total of 235 bacterial isolates were recovered
from sputum and bronchoalveolar lavage specimens obtained from
patients with LRTI. The specimens were collected during the period
from January 2012 to December 2012 from the microbiological diagnostic
laboratory of Sadr Al-Abbassiya hospital specialized in the treatment
of chest infections in Cairo, Egypt. The antimicrobial susceptibility
testing showed that the lowest resistance was observed to amikacin,
doxycycline and meropenem; only 19 isolates (8%) were resistant
to each. While the highest resistance was observed to clindamycin;
108 isolates (45.9%) were resistant. Among the collected isolates; 62
isolates (26.4%) were found to be resistant to 6 or more antimicrobial
agents; 53 isolates were Gram-negative (85.5%) while 9 isolates
were Gram-positive (14.5%). Out of these 62 MDR isolates; 23 isolates
were Klebsiella pneumoniae (37.1%), 15 isolates were Escherichia
coli (24.2%), 10 isolates were Pseudomonas aeruginosa (16.1%), 9
isolates were Staphylococcus aureus (14.5%), 3 isolates were Enterobacter
cloacae (4.8%) and 2 isolates were Acinetobacter baumannii
(3.2%). Most MDR organisms showed resistance to tested penicillin
derivatives, cephalosporins as well as co-trimoxazole and macrolide
antibiotics, with the exception of azithromycin . Conclusion: Multiple drug resistance is a major health concern limiting
the use of common antimicrobials in therapy. Guided prescription of
antimicrobial agents must be implemented and controlled in Egyptian
hospitals to limit further spread of antimicrobial resistance
Other data
Title | Antimicrobial resistance pattern of some bacterial pathogens involved in lower respiratory tract infections in Egypt | Authors | Aboshanab K. M. ; Abdelaziz, Salma ; Hassouna, Nadia A ; Aboulwafa, Mohammad M | Keywords | Lower respiratory tract infections;antimicrobial resistance;multiple drug resistance | Issue Date | 2015 | Journal | Acta Microbiologica | Volume | 6 | Issue | 1 | DOI | 10.3823/286 |
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