PROTECTIVE ROLE OF THE NIGELLA SATIVA OIL AGAINST
Zaazaa, Asmaa;
Abstract
Objective: Arsenic (As) exposure causes oxidative stress and tissue
damage in the rat brain. This study was under taken to investigate the
role of Nigella sativa oil (NSO) in ameliorate the neurotoxicity induced
by arsenic exposure in male rats. Design: Forty male Sprague Dawley
rats were divided into four groups each 10 rats, Group I (normal
control group): received saline solution orally. Group II (As group):
rats received arsenic as sodium arsenite orally (5 mg/kg bw/day) for 30
days. Group III (NSO group): rats administered orally with Nigella
sativa oil at a dose of (0.5 ml/kg bw/day) for 30 days. Group IV (As
+NSO group): rats received both sodium arsenite orally (5 mg/kg
bw/day) and NSO oil at a dose of (0.5 ml/kg bw/day) for 30 days. At
the end of the experimental period, rats were sacrificed; brain samples were obtained for
different biochemical analyses. The biochemical analyses included determination of tumor
necrosis factor-α (TNF-α), interleukin-1b (IL-1b), FAS, B-cell lymphoma 2 (Bcl2), Brain
derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). Results:
In comparison with normal control group, the As group recorded significant increase in the
brain levels of TNF-α, IL-1b, FAS and VEGF levels in brain tissue. On the other hand,
significant decrease in brain Bcl2 and BDNF levels were detected in As group as compared
to normal control group. In contrast, the treatment of As group with NSO caused an
improvement in the most studied biochemical parameters as indicated by decreased brain
levels of TNF-α, IL-1b, FAS and VEGF accompanied with significant increase in the levels
of Bcl2 and BDNF as compared to As group. Conclusion: This study revealed that Nigella
sativa oil significantly ameliorates the neuroinflammation and neurodegenerative disorders characterizing to neurotoxicity induced by sodium arsenite in male rats due to its antiinflammatory
property and antioxidant capacity.
damage in the rat brain. This study was under taken to investigate the
role of Nigella sativa oil (NSO) in ameliorate the neurotoxicity induced
by arsenic exposure in male rats. Design: Forty male Sprague Dawley
rats were divided into four groups each 10 rats, Group I (normal
control group): received saline solution orally. Group II (As group):
rats received arsenic as sodium arsenite orally (5 mg/kg bw/day) for 30
days. Group III (NSO group): rats administered orally with Nigella
sativa oil at a dose of (0.5 ml/kg bw/day) for 30 days. Group IV (As
+NSO group): rats received both sodium arsenite orally (5 mg/kg
bw/day) and NSO oil at a dose of (0.5 ml/kg bw/day) for 30 days. At
the end of the experimental period, rats were sacrificed; brain samples were obtained for
different biochemical analyses. The biochemical analyses included determination of tumor
necrosis factor-α (TNF-α), interleukin-1b (IL-1b), FAS, B-cell lymphoma 2 (Bcl2), Brain
derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF). Results:
In comparison with normal control group, the As group recorded significant increase in the
brain levels of TNF-α, IL-1b, FAS and VEGF levels in brain tissue. On the other hand,
significant decrease in brain Bcl2 and BDNF levels were detected in As group as compared
to normal control group. In contrast, the treatment of As group with NSO caused an
improvement in the most studied biochemical parameters as indicated by decreased brain
levels of TNF-α, IL-1b, FAS and VEGF accompanied with significant increase in the levels
of Bcl2 and BDNF as compared to As group. Conclusion: This study revealed that Nigella
sativa oil significantly ameliorates the neuroinflammation and neurodegenerative disorders characterizing to neurotoxicity induced by sodium arsenite in male rats due to its antiinflammatory
property and antioxidant capacity.
Other data
Title | PROTECTIVE ROLE OF THE NIGELLA SATIVA OIL AGAINST | Authors | Zaazaa, Asmaa | Keywords | Keywords: Sodium arsenite, Nigella sativa oil, anti-inflammatory, antioxidant capacity | Issue Date | 2014 | Publisher | World Journal of Pharmaceutical research | Journal | World Journal of Pharmaceutical research |
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