Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives
El-Shahawi, Manal M.; El-Ziaty, Ahmed;
Abstract
© 2017 Manal M. El-Shahawi and Ahmed K. El-Ziaty. 2-Amino-4,5-diphenylfuran-3-carbonitrile 1 was utilized as building block for the construction of new furo[2,3-d]pyrimidin-4(3H)-one derivative 2 and 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 via treatment with acetic anhydride and benzoyl chloride, respectively. The 4H-furo[2,3-d][1,3]oxazin-4-one derivative 3 was transformed into novel furo[2,3-d]pyrimidin-4(3H)-ones 4-8, tetrazolylfuran derivative 10, and furo[3,2-d]imadazolone derivative 11 via reaction with various nitrogen nucleophiles. The structure features of the synthesized compounds were established from their spectral and elemental analyses.
Other data
Title | Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3]oxazin-4-one and Furo[2,3-d]pyrimidin-4(3H)-one Derivatives | Authors | El-Shahawi, Manal M. ; El-Ziaty, Ahmed | Issue Date | 2017 | Journal | Journal of Chemistry | DOI | https://api.elsevier.com/content/abstract/scopus_id/85019006335 1 2017 10.1155/2017/5610707 |
Scopus ID | 2-s2.0-85019006335 |
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