Antioxidant and anti-cancer effect of Egyptian and European pumpkin seed oil

Al-Okbi S. ; Mohamed D. ; Kandil E. ; Ahmed, Emad ; Mohammed S. 


Abstract


The aim of the present research was to study the anti-cancer and in-vitro antioxidant activity of Egyptian and European pumpkin seed oil (PSO). The anti-cancer effect of the oils was examined in different human cancer cell lines represented by HepG-2 (liver cancer cells), MCF-7 (breast cancer cells) and Caco-2 (colon cancer cells). Results clarified that Egyptian PSO has significant higher antioxidant activity than the European (105.1 �8.3 and85.5�7.6, p < 0.05; respectively). The two oils could inhibit colon cancer cell line with an IC50value of 0.483mg. Egyptian oil showed higher anti-cancer activity than the European towards liver cancer cell while the Egyptian oil had lower activity towards breast cancer cell compared with the European oil.


Other data

Issue Date 1-Sep-2016
Journal Research Journal of Pharmaceutical, Biological and Chemical Sciences 
URI http://research.asu.edu.eg/handle/123456789/168408
DOI 5
https://api.elsevier.com/content/abstract/scopus_id/84987720599
574
7


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