Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

Al-Okbi, S.Y., Mohamed, D.A., Kandil, E., Abo-Zeid, M.A., Mohammed, S.E., Ahmed, Emad,

Abstract


© 2017 CSIC. The aim of the present research was to evaluate the anti-inflammatory activity of pumpkin seed oils (PSOs) of an Egyptian and European variety, in a rat model of adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-α (TNF-α) and erythrocyte sedimentation rate (ESR) were determined as inflammatory biomarkers while malondialdehyde (MDA) and total antioxidant capacity (TAC) were assessed as indicative of oxidative stress. Chromosomal aberration, sperm shape abnormalities, and DNA fragmentations are cytogenetic parameters which aid in tracing inflammatory and oxidative activity. Phenolic contents and β-carotene were determined in PSOs. The results showed elevated ESR, plasma TNF-α, plasma MDA, liver cellular DNA fragmentation, bone marrow chromosomal aberration, sperm shape abnormalities with a reduction in plasma TAC and body weight gain in an adjuvant arthritis control compared to a healthy control. Administration of low and high doses of either Egyptian or European PSO improved all the aforementioned parameters with vari-Able degrees.


Other data

Title Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats
Authors Al-Okbi, S.Y. ; Mohamed, D.A. ; Kandil, E. ; Abo-Zeid, M.A. ; Mohammed, S.E. ; Ahmed, Emad 
Issue Date 2017
Journal Grasas y Aceites 
DOI 1
180
http://www.scopus.com/inward/record.url?eid=2-s2.0-85016728160&partnerID=MN8TOARS
68
10.3989/gya.0796161
Scopus ID 2-s2.0-85016728160

Recommend this item

Similar Items from Core Recommender Database

Google ScholarTM

Check

Citations 6 in scopus
views 4 in Shams Scholar


Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.