Polyhalogenated heterocyclic compounds
Khalil, A. K.;
Abstract
Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3,5-dichloro-2,4,6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine derivative, via nucleophilic substitution of the methoxy group, rather than the dechlorinated products. Macrocycles can be synthesised by reactions of appropriate difunctional oxygen nucleophiles with 3,5-dichloro-2,4,6-trifluoropyridine, one of which was characterised by X-ray crystallography. © 2005 Elsevier B.V. All rights reserved.
Other data
Title | Polyhalogenated heterocyclic compounds | Authors | Khalil, A. K. | Issue Date | 2005 | Journal | Journal of Fluorine Chemistry | DOI | 7 https://api.elsevier.com/content/abstract/scopus_id/22244472604 1002 126 10.1016/j.jfluchem.2005.01.018 |
Scopus ID | 2-s2.0-22244472604 |
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