Polyhalogenated heterocyclic compounds

Khalil, A. K. 


Abstract


Model studies show that displacement of fluorine, rather than chlorine, occurs upon reaction of 3,5-dichloro-2,4,6-trifluoropyridine with sodium methoxide and phenoxide. Subsequent hydro-dechlorination can be achieved by reaction with lithium aluminium hydride whereas reaction of sodium in iso-propanol leads to formation of the tri-iso-propoxy pyridine derivative, via nucleophilic substitution of the methoxy group, rather than the dechlorinated products. Macrocycles can be synthesised by reactions of appropriate difunctional oxygen nucleophiles with 3,5-dichloro-2,4,6-trifluoropyridine, one of which was characterised by X-ray crystallography. © 2005 Elsevier B.V. All rights reserved.


Other data

Issue Date 2005
Journal Journal of Fluorine Chemistry 
URI http://research.asu.edu.eg/handle/123456789/168565
DOI 7
https://api.elsevier.com/content/abstract/scopus_id/22244472604
1002
126
10.1016/j.jfluchem.2005.01.018


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