Synthesis and Reactions of Novel 2,5-Disubstituted 1,3,4-Thiadiazoles

Mahmoud, Mahmoud R.; Shiba, Sayed A.; El-Ziaty, Ahmed; Abu El-Azm, Fatma S. M.; Ismail, Mahmoud F.;

Abstract


The desired 1,3,4-thiadiazole compounds bearing different substituents were obtained by the cyclization of the corresponding thiosemicarbazide followed by the reaction with electrophilic reagents, such as aromatic aldehydes, isatin, phenyl isothiocyanate, and carbon disulfide. The newly synthesized 2,5-disubstituted 1,3,4-thiadiazoles were obtained in good yields and their structures were elucidated by spectral data and elemental analysis. © 2014 Copyright Taylor & Francis Group, LLC.


Other data

Title Synthesis and Reactions of Novel 2,5-Disubstituted 1,3,4-Thiadiazoles
Authors Mahmoud, Mahmoud R. ; Shiba, Sayed A. ; El-Ziaty, Ahmed ; Abu El-Azm, Fatma S. M. ; Ismail, Mahmoud F. 
Issue Date 2014
Journal Synthetic Communications 
DOI 8
https://api.elsevier.com/content/abstract/scopus_id/84897901222
1094
44
10.1080/00397911.2013.846381
Scopus ID 2-s2.0-84897901222

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