Novel synthesis of some imidazolyl-, benzoxazinyl-, and quinazolinyl- 2,4-dioxothiazolidine derivatives

Youssef A., El-Ziaty, Ahmed, Abou-Elmagd W., Ramadan S.,

Abstract


© 2014 HeteroCorporation. 2-(2,4-Dioxothiazolidin-5-yl)acetic acid 1 and its chloride derivative 2 were allowed to react with different aromatic amines such as o-phenylenediamine, o-aminothiophenol, p-aminoacetophenone, and anthranilic acid to give the biologically active nuclei such as imidazoles, thiazoles, benzoxazines, and quinazolines incorporated with the thiazolidindione nucleus. The antimicrobial activity of five of the synthesized compounds was examined against one gram positive bacteria (Staphylococcus aureus), one gram negative bacteria (Escherichia coli), and two fungi (Aspergillus flavus and Candida albicans). Four compounds showed moderate antibacterial and antifungal activities.


Other data

Title Novel synthesis of some imidazolyl-, benzoxazinyl-, and quinazolinyl- 2,4-dioxothiazolidine derivatives
Authors Youssef A. ; El-Ziaty, Ahmed ; Abou-Elmagd W. ; Ramadan S. 
Issue Date 1-Jan-2015
Journal Journal of Heterocyclic Chemistry 
URI http://research.asu.edu.eg/handle/123456789/168603
DOI 1
https://api.elsevier.com/content/abstract/scopus_id/84921448072
278
52
10.1002/jhet.1943

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