β-Lactam Synthesis through Diodomethane Addition to Amide Dianions
Ali Khalil Ali;
Abstract
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We present a novel route for the quick and easy synthesis of a broad range of β-lactams. The synthesis involves a [3+1] cyclization of amide dianions with diiodomethane. In contrast to the seminal work of Hirai et al. from 1979, the reaction proved to be a general and efficient approach towards azetidinones. The ease of the process was confirmed by DFT calculations and its power demonstrated by a diversity-oriented synthesis of β-lactams with four points of diversity determined by the choice of Ugi adducts as starting materials.
Other data
Title | β-Lactam Synthesis through Diodomethane Addition to Amide Dianions | Authors | Ali Khalil Ali | Issue Date | 2017 | Journal | Angewandte Chemie International Edition | DOI | 40 12179 https://api.elsevier.com/content/abstract/scopus_id/85027983920 56 1521-3773 10.1002/anie.201706315 |
PubMed ID | 28741888 | Scopus ID | 2-s2.0-85027983920 |
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