Renal iron deposition by magnetic resonance imaging in pediatric β-thalassemia major patients: Relation to renal biomarkers, total body iron and chelation therapy
ElAlfy, Mohsen Saleh; Khalil Elsherif, Nayera Hazaa; Ebeid, Fatma Soliman Elsayed; Ismail, Eman Abdel Rahman; Ahmed, Khaled Aboulfotouh; Darwish, Yasser Wagih; S. IBRAHIM, Ahmed; Elghamry, Islam Reda Farag; Shokrey, Nermeen Adel; Alajeil, Dunia Naser;
Abstract
© 2018 Elsevier B.V. Background: The reciprocal of multiecho gradient-echo (ME–GRE) T2* magnetic resonance imaging (MRI) R2*, rises linearly with tissue iron concentration in both heart and liver. Little is known about renal iron deposition in β-thalassemia major (β-TM). Aim: To assess renal iron overload by MRI and its relation to total body iron and renal function among 50 pediatric patients with β-TM. Methods: Serum ferritin, serum cystatin C, urinary albumin creatinine ratio (UACR), and urinary β2-microglobulin (β2 M) were measured with calculation of β2 M/albumin ratio. Quantification of liver, heart and kidney iron overload was done by MRI. Results: Serum cystatin C, UACR and urinary β2 microglobulin as well as urinary β2m/albumin were significantly higher in β-TM patients than the control group. No significant difference was found as regards renal R2* between Patients with mean serum ferritin above 2500 μg/L and those with lower serum cutoff. Renal R2* was higher in patients with poor compliance to chelation therapy and positively correlated to indirect bilirubin, LDH, cystatin C and LIC but inversely correlated to cardiac T2*. Conclusion: kidney iron deposition impairs renal glomerular and tubular functions in pediatric patients with β-TM and is related to hemolysis, total body iron overload and poor compliance to chelation.
Other data
Title | Renal iron deposition by magnetic resonance imaging in pediatric β-thalassemia major patients: Relation to renal biomarkers, total body iron and chelation therapy | Authors | ElAlfy, Mohsen Saleh ; Khalil Elsherif, Nayera Hazaa ; Ebeid, Fatma Soliman Elsayed ; Ismail, Eman Abdel Rahman ; Ahmed, Khaled Aboulfotouh ; Darwish, Yasser Wagih ; S. IBRAHIM, Ahmed ; Elghamry, Islam Reda Farag ; Shokrey, Nermeen Adel ; Alajeil, Dunia Naser | Issue Date | 2018 | Publisher | ELSEVIER IRELAND LTD | Journal | European Journal of Radiology | DOI | 65 https://api.elsevier.com/content/abstract/scopus_id/85045381970 103 1872-7727 10.1016/j.ejrad.2018.04.007 |
PubMed ID | 29803388 | Scopus ID | 2-s2.0-85045381970 | Web of science ID | WOS:000433201500011 |
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