Pharmacological modulation of brain levels of glutamate and gABA in rats exposed to total sleep deprivation
ShamsElDine, Sahar;
Abstract
Abstract: Modulation of gamma-aminobutyric acid (GABA) and glutamate by selected
antidepressants and anticonvulsants could play a beneficial role in total sleep deprivation (TSD) caused by depressed mood. In the present study, albino rats were exposed to TSD for five days. On the sixth day, the brains were removed, and GABA and glutamate levels were measured in the prefrontal cortex and thalamus to identify TSD-induced changes in untreated rats and in rats treated with carbamazepine 40 mg/kg intraperitoneally (IP), fluoxetine 20 mg/kg IP, or desipramine 10 mg/kg IP. Carbamazepine and fluoxetine significantly increased GABA and reduced glutamate levels in both brain areas. Desipramine administration did not affect GABA or glutamate concentrations in the tested brain areas; levels were comparable with those induced by TSD without treatment. These results suggest that administration of carbamazepine or fluoxetine could have a beneficial effect by increasing GABA levels during TSD.
antidepressants and anticonvulsants could play a beneficial role in total sleep deprivation (TSD) caused by depressed mood. In the present study, albino rats were exposed to TSD for five days. On the sixth day, the brains were removed, and GABA and glutamate levels were measured in the prefrontal cortex and thalamus to identify TSD-induced changes in untreated rats and in rats treated with carbamazepine 40 mg/kg intraperitoneally (IP), fluoxetine 20 mg/kg IP, or desipramine 10 mg/kg IP. Carbamazepine and fluoxetine significantly increased GABA and reduced glutamate levels in both brain areas. Desipramine administration did not affect GABA or glutamate concentrations in the tested brain areas; levels were comparable with those induced by TSD without treatment. These results suggest that administration of carbamazepine or fluoxetine could have a beneficial effect by increasing GABA levels during TSD.
Other data
Title | Pharmacological modulation of brain levels of glutamate and gABA in rats exposed to total sleep deprivation | Authors | ShamsElDine, Sahar | Keywords | total sleep deprivation, antidepressants, carbamazepine, GABA, glutamate, rats | Issue Date | 3-Jun-2010 | Publisher | Dovepress | Journal | Journal of Experimental Pharmacology | Description | Experimental neuropsychopharmacology |
Attached Files
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JEP-11143-pharmacological-modulation-of-brain-levels-of-glutamate-and-_060410[1][1].pdf | 258.99 kB | Adobe PDF | Request a copy |
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