Synthesis and antimicrobial activity evaluation of some novel heterocycles derived from chromonyl-2(3H)-furanone
Ramadan, S. K.; El-Helw E.;
Abstract
© 2018 Science Reviews 2000 Ltd. All rights reserved. 6-Chloro-3-((2-oxo-5-phenylfuran-3(2H)-ylidene)methyl)-4H-chromen-4-one was utilised for the construction of N-heterocycles. The proclivity of this furanone towards some nitrogen nucleophiles, i.e. glycine, thiosemicarbazide, thiocarbohydrazide, phenylhydrazine and o-phenylenediamine, was studied. The structures of all products obtained were established on the basis of their analytical and spectral data. All synthesised compounds were screened for their in vitro antibacterial (two strains of bacteria; Escherichia coli and Staphylococcus aureus) and antifungal (two fungus strains; Aspergillus flavus and Candida albicans) activities. Some products exhibited promising antimicrobial activities.
Other data
Title | Synthesis and antimicrobial activity evaluation of some novel heterocycles derived from chromonyl-2(3H)-furanone | Authors | Ramadan, S. K. ; El-Helw E. | Issue Date | 1-Jun-2018 | Publisher | SCIENCE REVIEWS 2000 LTD | Journal | Journal of Chemical Research | DOI | 6 332 https://api.elsevier.com/content/abstract/scopus_id/85052022476 42 10.3184/174751918X15295796734379 |
Scopus ID | 2-s2.0-85052022476 | Web of science ID | WOS:000438096900013 |
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