Photodynamic therapeutic activity of indocyanine green entrapped in polymeric nanoparticles
El-Daly, Sherien M; Gamal-Eldeen, Amira M; Abo-Zeid, Mona A M; Borai, Ibrahim H; Wafay, Hanaa A; Abdel-Ghaffar, Abdel-Rahman;
Abstract
Photodynamic therapy (PDT) is a therapeutic modality involving the use of a photosensitizer agent activated by light of appropriate wavelength to selectively destroy tumor cells. Indocyanine green (ICG) is a promising photosensitive agent for PDT of tumor cells. The main disadvantage of using ICG in PDT is the instability of ICG in aqueous solutions. Encapsulating ICG dye in a biocompatible matrix based on PEBBLE technology showed an improvement of aqueous stability comparing with free ICG dye. The main objective of this study is to investigate the photodynamic effect of ICG-ormosil PEBBLEs on two different cell lines: human breast adenocarcinoma cells (MCF-7) and hepatocellular carcinoma cells (HepG2).
Other data
| Title | Photodynamic therapeutic activity of indocyanine green entrapped in polymeric nanoparticles | Authors | El-Daly, Sherien M ; Gamal-Eldeen, Amira M ; Abo-Zeid, Mona A M ; Borai, Ibrahim H ; Wafay, Hanaa A ; Abdel-Ghaffar, Abdel-Rahman | Issue Date | May-2013 | Publisher | ELSEVIER SCIENCE BV | Journal | Photodiagnosis and photodynamic therapy | DOI | 173-85 1873-1597 2 185 https://api.elsevier.com/content/abstract/scopus_id/84879271366 10 10.1016/j.pdpdt.2012.08.003 |
PubMed ID | 23769284 | Scopus ID | 2-s2.0-84879271366 | Web of science ID | WOS:000321536400012 |
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