Effect of Pleurotus Ostreatus on the endothelial dysfunction in ovariectomized-diabetic rats

Abstract

© 2017 @ author (s). We designed this study to evaluate the effect of Pleurotus Ostreatus mushroom on the endothelial dysfunction in ovariectomized-diabetic rats. In this study 70 female Sprague-Dawley rats were divided into 7 groups: control group, healthy rats received orally 100mg/kg body weight mushroom, healthy rats received orally 200mg/kg body weight mushroom, Sham group, ovariectomized-diabetic rats, treated ovariectomized-diabetic rats received orally 100mg/kg body weight mushroom and treated ovariectomized-diabetic rats received orally 200mg/kg body weight mushroom. Blood samples were collected for assessment of fasting sugar, insulin, estrogen, lipid profile, paraoxonase (PON1) and asymmetric dimethylargnine (ADMA). Aorta tissues were used to determine nitric oxide (NO) and tissue plasminogen activator t-PA. Treatment with Pleurotus Ostreatus showed a significant decrease in levels of fasting sugar, estrogen, total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholesterol (LDL-C), and ADMA. Otherwise, insulin, high density lipoprotein cholesterol (HDL-C), PON1, NO and t-PA were significantly increased compared to ovariectomized-diabetic rats. In conclusion, it has been demonstrated that Pleurotus Ostreatus has favorably effects on serum lipids, improves endothelium-dependent vasodilatation, increase estrogen level which decrease intravascular thrombus propagation. These findings have generated proposed mechanisms for Pleurotus Ostreatus to improve endothelial dysfunction and protect against the development of atherosclerosis in ovariectomized-diabetic rats.