Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: Possible neuromodulation and antioxidant mechanisms
Mahdy, H.M.; Mohamed, M.R.; emam, Manal; Karim, A.M.; Abdel-Naim, A.B.; Khalifa, A.E.;
Abstract
Puerarin (daidzein-8-C-glucoside), a major isoflavone glycoside purified from Pueraria lobata, is well reported to have a neuroprotective effect primarily by the antioxidant mechanisms. This investigation was designed to evaluate the efficacy of Puerarin (Pur) to offset 3-nitropropionic acid (3-NP) induced neurotoxicity. Male Wistar strain rats were given 3-NP (20 mg/kg, s.c.) over five consecutive days, whereas Pur (200 mg/kg, i.p.) was administrated 30 min before 3-NP. Rats treated with 3-NP exhibited significant weight loss, reduction of the prepulse inhibition, locomotor hypoactivity and hypothermia. The striata, hippocampi and cortices of the 3-NP treated rats showed abnormal levels of neurotransmitters, oxidative damage and characteristic histopathological lesions. Treatment with Pur ahead of 3-NP, significantly prevented weight loss, PPI deficit, locomotor hypoactivity and hypothermia. Pur treatment blocked the 3-NP-induced neurotransmitters abnormalities (GABA, DA, 5-HT and NE), and normalized the oxidative stress biomarkers (lipid peroxidation, reduced glutathione, glutathione peroxidase). Histopathological examination further affirmed Pur's neuroprotective effect against 3-NP-induced neurotoxicity. In conclusion, Pur protected the brain tissues from 3-NP induced neurotoxicity primarily by its neuromodulation and antioxidant effect. © 2013 Springer Science+Business Media New York.
Other data
Title | Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: Possible neuromodulation and antioxidant mechanisms | Authors | Mahdy, H.M. ; Mohamed, M.R. ; emam, Manal ; Karim, A.M. ; Abdel-Naim, A.B. ; Khalifa, A.E. | Issue Date | 2014 | Journal | Neurochemical Research | DOI | 321 1573-6903 2 332 http://www.scopus.com/inward/record.url?eid=2-s2.0-84895111382&partnerID=MN8TOARS 39 10.1007/s11064-013-1225-7 |
PubMed ID | 39 | Scopus ID | 2-s2.0-84895111382 |
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