Copper (II)-surfactant complex and its nano analog as potential antitumor agents

Badawi A. ; Zakhary N. ; Morsy S. ; Mahmoud Shouckry, Gilane Mohamed Sabry ; Mohamed M. ; Mousa A. 


Abstract


The in vitro anticancer activity of copper cetyl trimethyl ammonium bromide (Cu-CTAB)-loaded cyclodextrin nanoparticles on Ehrlich ascites carcinoma (EAC), colon cancer cells (HCT 116), liver cancer cells (HepG-2), breast cancer cells (MCF-7), and cervix cancer cells (Hela) was investigated using MTT due assay. Cyclodextrin nanoparticles loaded with Cu-CTAB exerted in vitro anticancer activity against the previous human cancer cell lines comparable to the activity of free non-entrapped in nanoparticles macro-particle Cu-CTAB. The nano analog was synthesized by physical loading using grinding with ball mill. The ratio between Cu-CTAB and cyclodextrin oligosaccharide was 1 Cu-CTAB: 3 cyclodextrin. The particle size of the nano derivative was determined using the transmitted electron microscope (TEM). © Taylor & Francis Group, LLC.


Other data

Issue Date 1-Oct-2009
Publisher TAYLOR & FRANCIS INC
Journal Journal of Dispersion Science and Technology 
URI http://research.asu.edu.eg/handle/123456789/170002
DOI 1303
9
1309
https://api.elsevier.com/content/abstract/scopus_id/70449427624
30
10.1080/01932690902735439


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