Possible therapeutic uses of salvia triloba and piper nigrum in alzheimer's disease-induced rats

Ahmed, H.H., Salem, A.M., Mahmoud Shouckry, Gilane Mohamed Sabry, Husein, A.A., Kotob, S.E.,

Abstract


This study aimed to investigate the role of Salvia triloba L. and Piper nigrum extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley rats were classified into Group 1 (n=10): normal healthy animals serving as the negative control group; Group 2 (n=60): the AD-induced group. After AD induction, animals in the AD-induced group were divided randomly and equally into 6 subgroups. The first subgroup served as AD control; the second one, which served as positive control, was treated orally with the conventional therapy for AD (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The third and fourth subgroups were, respectively, treated orally with the S. triloba extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and sixth subgroups were, respectively, treated orally with the P. nigrum extract at a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, C-reactive protein (CRP), total nuclear factor kappa-B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were estimated. The results showed that administration of AlCl3 resulted in a significant elevation in the levels of AchE activity, CRP, NF-κB, and MCP-1 accompanied with a significant depletion in the Ach level. Treatment of AD rats with each of the selected medicinal plant extracts caused marked improvement in the measured biochemical parameters. In conclusion, S. triloba and P. nigrum methanolic extracts have potent anti-inflammatory effects against neuroinflammation characterizing AD. © Copyright 2013, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2013.


Other data

Title Possible therapeutic uses of salvia triloba and piper nigrum in alzheimer's disease-induced rats
Authors Ahmed, H.H. ; Salem, A.M. ; Mahmoud Shouckry, Gilane Mohamed Sabry ; Husein, A.A. ; Kotob, S.E. 
Issue Date 2013
Publisher MARY ANN LIEBERT INC
Journal Journal of Medicinal Food 
DOI 437
1557-7600
5
446
http://www.scopus.com/inward/record.url?eid=2-s2.0-84877873056&partnerID=MN8TOARS
16
10.1089/jmf.2012.0165
PubMed ID 16
Scopus ID 2-s2.0-84877873056
Web of science ID WOS:000319256900009

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