Some divalent metal(II) complexes of novel potentially tetradentate Schiff base N,N′-bis(2-carboxyphenylimine)-2,5-thiophenedicarboxaldhyde: Synthesis, spectroscopic characterization and bioactivities

Abdel Aziz, Ayman, Ibrahim S.A. El-Sayed, Mostafa M.H. Khalil,

Abstract


Copyright © 2017 John Wiley & Sons, Ltd. A novel tetradentate dianionic Schiff base ligand, N,N′-bis(2-carboxyphenylimine)-2,5-thiophenedicarboxaldhyde (H2L) and some first row d-transition metal chelates (Co(II), Cu(II), Ni(II) and Zn(II)) were synthesized and characterized using various physicochemical and spectroscopic methods. The spectroscopic data suggested that the parent Schiff base ligand coordinates through both deprotonated carboxylic oxygen and imine nitrogen atoms. The free Schiff base and its metal chelates were screened for their antimicrobial activities for various pathogenic bacteria and fungi using the agar well diffusion method. The antibacterial and antifungal activities of all the newly synthesized compounds are significant compared to the standard drugs ciprofloxacin and nystatin. The antioxidant activities of the compounds were determined by reduction of 1,1-diphenyl-2-picrylhydrazyl and compared with that of vitamin C as a standard. DNA binding ability of the novel Schiff base and its complexes was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and thermal denaturation. The obtained results clearly demonstrate that the binding affinity with calf thymus DNA follows the order: Cu(II) complex > Ni(II) complex > Zn(II) complex > Co(II) complex >H2L. Furthermore, the DNA cleavage activity of the newly synthesized ligand and its metal complexes was investigated using supercoiled plasmid DNA (pUC18) gel electrophoresis.


Other data

Title Some divalent metal(II) complexes of novel potentially tetradentate Schiff base N,N′-bis(2-carboxyphenylimine)-2,5-thiophenedicarboxaldhyde: Synthesis, spectroscopic characterization and bioactivities
Authors Abdel Aziz, Ayman ; Ibrahim S.A. El-Sayed ; Mostafa M.H. Khalil 
Issue Date 2017
Publisher WILEY
Journal Applied Organometallic Chemistry 
DOI e3730
10
https://api.elsevier.com/content/abstract/scopus_id/85016439945
31
10.1002/aoc.3730
Scopus ID 2-s2.0-85016439945
Web of science ID WOS:000411764500020

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