Synthesis, structural features and biochemical activity assessment of N,N′-bis-(2-mercaptophenylimine)-2,5-thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Abdel Aziz, Ayman, Sabry H. Seda,

Abstract


Copyright © 2017 John Wiley & Sons, Ltd. The tetradentate Schiff base ligand (SB), N,N′-bis-(2-mercaptophenylimine)-2,5-thiophenedicarboxaldehyde was prepared via condensation of 2,5-thiophene-dicarboxaldehyde with 2-aminothiophenol in a 1:2 molar ratio by conventional method. Additionally, its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and fully characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR, UV–Vis, ESR, ESI-mass, conductivity and magnetic susceptibility measurements. Spectral studies suggested that, the Schiff base coordinate metal ions through the azomethine N- and deprotonated thiol S- atoms. Based on UV–Vis absorption and magnetic susceptibility data, tetrahedral geometry was assigned for both Co(II) and Zn(II) complexes, whereas on the other hand, square planar geometry for both Ni(II) and Cu(II) complexes. The Schiff base and its metal complexes were screened for their in vitro antimicrobial activity by minimum inhibitory concentration (MIC) method. Free radical scavenging activity of the novel compounds was determined by elimination of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. In addition, the interactions of the free ligand and its complexes with calf thymus DNA (CT-DNA) were explored using absorption, emission and viscosity measurements techniques.


Other data

Title Synthesis, structural features and biochemical activity assessment of N,N′-bis-(2-mercaptophenylimine)-2,5-thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes
Authors Abdel Aziz, Ayman ; Sabry H. Seda 
Issue Date 2017
Publisher WILEY
Journal Applied Organometallic Chemistry 
DOI e3879
12
https://api.elsevier.com/content/abstract/scopus_id/85020432229
31
10.1002/aoc.3879
Scopus ID 2-s2.0-85020432229
Web of science ID WOS:000419195800062

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