Novel Synthesis of Some Phthalazinone Derivatives
Mahmoud, MR; Abou-Elmagd, WSI; Derbala, HA; Hekal, Mohamed;
Abstract
Dimethyl homophthalate condensed with isatin to give the unexpected five membered lactone 3 rather than the half ester 1 and the δ-lactone 2. Treatment of compound 3 with excess hydrazine hydrate afforded phthalazinone carbohydrazide 4 which represents a novel method for the synthesis of phthalazinone derivatives. The carbohydrazide 4 upon treatment with carbon disulphide afforded 1,3,4-oxadiazole derivative 5, which reacted with ethylchloroacetate to give the S-alkylated product 6. The structure of compound 3 compared with 2 was discussed using hyperchem professional (7) AM1calculations, X-ray single crystal structure and complete spectral data. Copyright © 2011 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Other data
| Title | Novel Synthesis of Some Phthalazinone Derivatives | Authors | Mahmoud, MR ; Abou-Elmagd, WSI ; Derbala, HA ; Hekal, Mohamed | Issue Date | 2011 | Publisher | WILEY-BLACKWELL | Journal | CHINESE JOURNAL OF CHEMISTRY | DOI | 1446 7 1450 https://api.elsevier.com/content/abstract/scopus_id/79960961022 29 10.1002/cjoc.201180264 |
Scopus ID | 2-s2.0-79960961022 | Web of science ID | WOS:000293697500022 |
Attached Files
| File | Description | Size | Format | |
|---|---|---|---|---|
| paper 1.pdf | 90.36 kB | Unknown | View/Open |
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