New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation
Hekal, Mohamed; Abu El-Azm,; FSM;
Abstract
© 2018, © 2018 Taylor & Francis. Since the quinazoline and its derivatives have been considered as a novel class of cancer chemotherapeutic agents that show promising activity against different tumors, a new series of 6-iodo-2-undecylquinazolin-4(3H)-ones were prepared via reaction of 6-iodo-2-undecyl-4H-benzoxazin-4-one with nitrogen nucleophiles, namely, primary amines, 4-amino antipyrine, hydrazine hydrate, diamines, ethanol amine, and/or hydrazide derivatives and screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely; hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 14, 16, and 18 showed remarkable broad spectrum antitumor activity. All compounds were fully characterized by means of IR, MS, and 1H-NMR spectra.
Other data
Title | New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: Synthesis and cytotoxic evaluation | Authors | Hekal, Mohamed ; Abu El-Azm, ; FSM | Issue Date | 2018 | Publisher | TAYLOR & FRANCIS INC | Journal | SYNTHETIC COMMUNICATIONS | DOI | 2391 18 2402 https://api.elsevier.com/content/abstract/scopus_id/85054842569 48 10.1080/00397911.2018.1490433 |
Scopus ID | 2-s2.0-85054842569 | Web of science ID | WOS:000449530700008 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.