Fluoroquinolones Resistance and its Potential Underlying Mechanisms in some Gram Negative Bacterial Isolates Recovered from Infected Cancer Patients

Abstract

In the current study, a total of 239 Gram negative isolates were recovered from different clinical specimens of infected cancer patients attending the NCI, Cairo, Egypt, in the period from November 2014 to July 2015. One hundred and fifty isolates (62.8%) were recovered from pediatric patients while 89 (37.2%) were recovered from adult patients. The majority of isolates were from blood (57.3%) followed by wound swabs (10.5%), pus (9.6%), sputum (7.5%), stools (4.6%), urine (4.2%), drain (3.3%), bronchoalveolar lavage (1.7%) and chest tubes (1.3%). The collected isolates were identified using the conventional microbiological techniques and confirmed by Vitek GN cards. The recovered isolates were identified as E. coli (39.7%), K. pneumoniae (34.3%), A. baumannii (10%), P. aeruginosa (7.9%) and other Gram negative isolates (7.9%) comprising Ent. cloacae (3.3%), E. aerogenes (2.1%), K. oxytoca (1.3%), P. mirabilis (0.8%) and C. freundii (0.4%).