Chitosan, Chitosan Nanoparticles and Chlorhexidine Gluconate as Intracanal Medicaments in Primary Teeth: An In-vivo Study

Abstract

Within the limitations of this study it can be concluded that: 1- Both 0.5 % chitosan nanoparticles and 1 % chlorhexidine gluconate intracanal medicaments in gel formulation have antibacterial effect against primary root canal bacteria, collectively, as well as Enterococcus faecalis. 2- Both 0.5 % chitosan and 0.5% chitosan nanoparticles medicament showed lower antibacterial effect against Staphylococcus aureus combared to 1 % chlorhexidine gluconate gel. 3- 0.5 % chitosan intracanal medicament in gel formulation showed no antibacterial effect against primary root canal bacteria and minimal antibacterial effect against Enterococcus faecalis, probably duo to its alkaline pH. 4- 0.5% chitosan nanoparticles and 1 % chlorhexidine gluconate gel showed better clinical and radiographic success rates at 3 and 6 months, compared to 0.5% chitosan.