EVALUATION OF MAGNESIUM SULFATE AS SUPPLEMENT FOR ANALGESIA AFTER LOWER ABDOMINAL SURGERY

Abstract

Pain after lower abdominal surgery may be moderate or even severe in some patients and require more than opioid treatment. Inadequately treated pain is a major cause of increased postoperative morbidity. The sympathetic stimulation resulting from pain can lead to tachycardia, arrhythmias, hypertension and increased myocardial strain and oxygen demands. Also, the pulmonary functions can be dramatically diminished by surgically induced pain which is usually secondary to reduced ability to cough to expand the lungs and clear secretions. The study was carried on eighty adult patients, ASA physical status I, and II scheduled for elective abdominal hystrectomy. Patients were randomly allocated into four groups, each of 20 patients. Group Ireceived morphine 10 mg IM only (control group). Group II received morphine 10 mg IM and Mg504 8 mg/kg/hr infusion after 50 mg/kg Mg504 slow IV push over 1 hour. Group IIIreceived morphine 10 mg IM, then Mg504 12 mg/kg/hr infusion after 50 mg/kg IV slow push over one hour. Group IV received morphine 10 mg IM immediate postoperatively followed by MgS04 infusion with a rate of 16 mg/kg/hr after 50 mg/kg slow IV push over 1 hour. The aim of the present study was to evaluate Mg504 as a supplement to morphine as analgesic after lower abdominal surgery with the accompanied hemodynamic changes.