P 53 GENE MUTATIONS AND SKIN CARCINOGENESIS

AL-HASSAN M.EL-HEFNAWI,

Abstract


The process of carcinogenesis in the skin was the main interest of this study. XP patients were good candidates for that, due to their high liability to develop cancer, but also non­ XP cancer patients were studied as well.
In general, the process of carcinogenesis is controlled by cancer genes, and they could be classified into three major categories:
• Those activate proliferation (oncogenes), e.g. Proto­
oncogenes.
• Those participate in DNA repair.
• Those normally inhibit cellular proliferation (tumor suppression) e.g. P53 gene which was the main factor of discussion in this study, and how this gene and its mutations would affect the development of cancer.
The genetic study of P53 gene was done through DNA analysis from tissue biopsies of cancer lesions by PCR to detect the gene and its mutations.
In order to understand the genetic process of carcinogenesis, the structure of DNA had to be explained, showing the four different bases (Thymine - Cytosine - Adenine - Guanine}, and how they are attached to the ribose sugar from one side,and the phosphate group from the other side to constitute the unit ofDNA which is the nucleotides, and the connection between these nuleotides constitute DNA.


Other data

Title P 53 GENE MUTATIONS AND SKIN CARCINOGENESIS
Other Titles تشوهات جين بي 53 فى سرطانات الجلد
Authors AL-HASSAN M.EL-HEFNAWI
Issue Date 2002
URI http://research.asu.edu.eg/handle/123456789/170536

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