Role of Bone Marrow (Non-hematopoietic Stem Cells) on Random Skin Flaps in A Rat Model ( Experimental Study

Abstract

Random-pattern skin flap is one of the most widely used tools in the repair of tissue defects in plastic surgery. However, its utility is limited by unpredictable blood supply, which sometimes results in partial flap necrosis which represents a great challenge. This problem therefore limits the use of random-pattern skin flaps. Different methods to improve skin flap survival have been employed which may be pharmacological or surgical. Surgical delay and ischemic preconditioning is the most effective method of increasing survival area. However, the delay procedure requires an additional operative procedure. Many researchers have focused on drug therapy as an alternative method for augmenting blood flow rather than the time consuming surgical delay. The pharmacological drugs mimics the surgical delay, however, the effects of drugs are transient and unstable.