Human Albumin Considerations in Anesthesia And Intensive Care Unit
Mohamed Husny Hafez El-Gafy;
Abstract
Albumin is the most abundant plasma protein, accounting for 60% of the measured serum protein, it is formed of single polypeptide chain, and it is highly soluble, with strong negative charge. It is heart shaped molecule, and it provides approximately
80% of the intravascular colloid oncotic pressure in normal
persons.
The serum albumin concentration is a function of its rates of synthesis, degradation and its distribution between the intravascular and extravascular compartments. The plasma compartment holds about 42% of the total albumin, the rest being in extravascular compartment so albumin is predominantly an extravascular protein. There is a dynamic equilibrium, which maintains the concentrations within the various compartments.
Albumin synthesis takes place only in liver, and it is not stored by the liver, the rate of synthesis varies with nutritional, hormonal, osmotic environment and disease states.
Albumin is broken down in most organs of the body especially muscles, skin, liver, kidneys and gastrointestinal tract.
Unlike synthetic colloids, albumin has many physiological functions. It has transport function and binds anions like bilirubin and hematin, cations like calcium and magnesium; it also can bind steroids, thyroxin and many other drugs.
80% of the intravascular colloid oncotic pressure in normal
persons.
The serum albumin concentration is a function of its rates of synthesis, degradation and its distribution between the intravascular and extravascular compartments. The plasma compartment holds about 42% of the total albumin, the rest being in extravascular compartment so albumin is predominantly an extravascular protein. There is a dynamic equilibrium, which maintains the concentrations within the various compartments.
Albumin synthesis takes place only in liver, and it is not stored by the liver, the rate of synthesis varies with nutritional, hormonal, osmotic environment and disease states.
Albumin is broken down in most organs of the body especially muscles, skin, liver, kidneys and gastrointestinal tract.
Unlike synthetic colloids, albumin has many physiological functions. It has transport function and binds anions like bilirubin and hematin, cations like calcium and magnesium; it also can bind steroids, thyroxin and many other drugs.
Other data
| Title | Human Albumin Considerations in Anesthesia And Intensive Care Unit | Other Titles | اعتبارات الألبومين البشرى فى التخدير ووحدة الرعاية المركزة | Authors | Mohamed Husny Hafez El-Gafy | Issue Date | 2002 |
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