P153 AND Kl-67 EXPRESSION IN SOME PROLIFERATIVE BENIGN AND MALIGNANT SKIN LESIONS

ELHAM ABDEL-AZIZ SARHAN,

Abstract


P53 is a tumour suppressor gene which regulates the cell growth. It

1s located on chromosome 17 P and encodes a 53 Kd phosphoprotein. This PS3 protein exerts important biological activities in various normal
and pathological human tissues.


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P53 in its natural form or "wild type" can bind to DNA and prevent cells from entering into the S-phase ofthe cell cycle. This wild type P53 acts as a potent suppressor of uncontrolled cell division.

P53 is present in the nucleus of' all mammalian cells, usually at a concentration below the detection level for immunohistochemical methods, mainly due to its short half-life. In contrast mutation of P53 gene produces a P53 protein with a prolonged half-life that may reach a concentration in the cells that allows immunohistochemichal detection. Mutant P53 gene has the ability to transform cells and lead to tumorigenesi's.
P53 IS frequently mutated in human cancers especialy non­ melanoma skin cancers. But there is marked controversy about its role in benign hyperproliferative skin disorders.


• Ki-67 which is a nuclear antigen 1s a reliable biomarker for the detection ofproliferating cells in tissue samples.


The aim of this study was to identify the expression ofP53 protein and Ki--67 in psoriatic skin as well as in BCC and SCC. Also to detect DNA ploidy of cells in these diseases.


Other data

Title P153 AND Kl-67 EXPRESSION IN SOME PROLIFERATIVE BENIGN AND MALIGNANT SKIN LESIONS
Other Titles ظهور ب 53 و ك اى 67 فى بعض الاصابات الجلدية المتكاثرة الحميدة والخبيثة دراسة اكلينيكية ومناعية
Authors ELHAM ABDEL-AZIZ SARHAN
Issue Date 2001
URI http://research.asu.edu.eg/handle/123456789/170684

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