NEURAL TISSUE TRANSPLANTATION
Hasan Mohammad Jalalod-din Al-Kalea;
Abstract
Although its roots date back over a century, the field of neurotransplantation has been shaped mostly by advances over the past 30 years.
Brain transplantation is defined as the placement into the CNS of tissue that has potential to restore physiologic functions that have been lost as a result of either trauma or degenerative disease.
Currently, the clinical problem most activily investigated for neural grafting is Parkinson's disease. Clinical investigations of Alzheimer's disease and Huntington's disease also are under wasy. Cerebral ischemia, spinal cord injury, and CNS developmental anomalies are additional major areas of neurologic dysfunction in which neural transplantation techniques may someday play a meaningful therapeutic role.
The mechanisms of neural graft-host interactions are still being defined. They may take the form of a biochemical sour-ce, neuronal replacement, aid recovery of damaged neurons, supply trophic factors to stimulate function or a bridge mechanisms.
The type of tissue used for grafting is selected according to its ultimate function, availability, associated risks, and ethical constraints.
Brain transplantation is defined as the placement into the CNS of tissue that has potential to restore physiologic functions that have been lost as a result of either trauma or degenerative disease.
Currently, the clinical problem most activily investigated for neural grafting is Parkinson's disease. Clinical investigations of Alzheimer's disease and Huntington's disease also are under wasy. Cerebral ischemia, spinal cord injury, and CNS developmental anomalies are additional major areas of neurologic dysfunction in which neural transplantation techniques may someday play a meaningful therapeutic role.
The mechanisms of neural graft-host interactions are still being defined. They may take the form of a biochemical sour-ce, neuronal replacement, aid recovery of damaged neurons, supply trophic factors to stimulate function or a bridge mechanisms.
The type of tissue used for grafting is selected according to its ultimate function, availability, associated risks, and ethical constraints.
Other data
| Title | NEURAL TISSUE TRANSPLANTATION | Other Titles | زراعة الأنسجة العصبية | Authors | Hasan Mohammad Jalalod-din Al-Kalea | Issue Date | 2002 |
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