THE EFFECTS OF DIETARY ARTIFICIAL COLORS ON EXPERIMENTAL RATS
Fatma Kamal Abd El-Hamid Mohamed;
Abstract
ABSTRACT
Recently the use of synthetic food coloring additives was increased and the levels of human exposure to such agents are very broad, thus feeding over long periods may continually possess potential hazards to the human health. Evaluation of the toxic effects of synthetic dyes brilliant blue, Tartrazine and Carmoisine were tested in rats by measuring their actions on renal, hepatic function, lipid profile, blood glucose, body-weight gain and hemoglobin concentration. Rats were fed synthetic dyes supplemented diet , daily for 60 and 90 days orally in two doses, one low and the other high dose followed by serum and tissue sample collection for determination of ALT, AST, ALP, urea, creatinine, uric acid , lipid profile, fasting blood glucose in serum and estimation of hemoglobin concentration. Our data showed a significant increase in ALT, AST, ALP, in addition to serum urea and creatinine levels in treated rats, While, they recorded a significant decrease in percentage of body weight change,HB concentration. Histopathological examinations revealed alterations in kidneys include: congestion and proteinaceous material in the lumen of renal tubules and perivascular oedema. Whereas alterations in liver include: focal necrosis of hepatocytes, vacuolation and. hydropic degeneration of hepatocytes and congestion of hepatic sinusoids.
Recently the use of synthetic food coloring additives was increased and the levels of human exposure to such agents are very broad, thus feeding over long periods may continually possess potential hazards to the human health. Evaluation of the toxic effects of synthetic dyes brilliant blue, Tartrazine and Carmoisine were tested in rats by measuring their actions on renal, hepatic function, lipid profile, blood glucose, body-weight gain and hemoglobin concentration. Rats were fed synthetic dyes supplemented diet , daily for 60 and 90 days orally in two doses, one low and the other high dose followed by serum and tissue sample collection for determination of ALT, AST, ALP, urea, creatinine, uric acid , lipid profile, fasting blood glucose in serum and estimation of hemoglobin concentration. Our data showed a significant increase in ALT, AST, ALP, in addition to serum urea and creatinine levels in treated rats, While, they recorded a significant decrease in percentage of body weight change,HB concentration. Histopathological examinations revealed alterations in kidneys include: congestion and proteinaceous material in the lumen of renal tubules and perivascular oedema. Whereas alterations in liver include: focal necrosis of hepatocytes, vacuolation and. hydropic degeneration of hepatocytes and congestion of hepatic sinusoids.
Other data
| Title | THE EFFECTS OF DIETARY ARTIFICIAL COLORS ON EXPERIMENTAL RATS | Other Titles | تأثير الألوان الصناعية الغذائية على فئران التجارب | Authors | Fatma Kamal Abd El-Hamid Mohamed | Issue Date | 2018 |
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