The Effect of Silver and Chitosan Nanoparticles Loaded with Spiramycin on Toxoplasmosis
Hanaa Kamil Hamad;
Abstract
Toxoplasma infection can cause severe consequences
during pregnancy and immunodeficient hosts, yet no effective
drug therapy has been approved till now. Thus, evaluation of
new potential drugs against toxoplasmosis is increasingly
necessary.
In the present study, the efficacy of silver and chitosan
nanoparticles loaded spiramycin were evaluated in mice
infected with toxoplasmosis. The study was conducted on 160
laboratory CD1 mice with a weight range of 20-25 gm. The
animals male were provided by the Schistosome biological
supply program (SBSP) at Theodor Bilharz Research Institute
(TBRI).The normal control group contained 10 mice. The rest
of the experimental animals were divided to 10 groups each
group contained 15 mice. RH virulent strains of T. gondii were
injected intra peritoneal in Swiss albino mice for acute infection
103 viable tachyzoites / mice. The administration
during pregnancy and immunodeficient hosts, yet no effective
drug therapy has been approved till now. Thus, evaluation of
new potential drugs against toxoplasmosis is increasingly
necessary.
In the present study, the efficacy of silver and chitosan
nanoparticles loaded spiramycin were evaluated in mice
infected with toxoplasmosis. The study was conducted on 160
laboratory CD1 mice with a weight range of 20-25 gm. The
animals male were provided by the Schistosome biological
supply program (SBSP) at Theodor Bilharz Research Institute
(TBRI).The normal control group contained 10 mice. The rest
of the experimental animals were divided to 10 groups each
group contained 15 mice. RH virulent strains of T. gondii were
injected intra peritoneal in Swiss albino mice for acute infection
103 viable tachyzoites / mice. The administration
Other data
| Title | The Effect of Silver and Chitosan Nanoparticles Loaded with Spiramycin on Toxoplasmosis | Other Titles | تأثير جسيمات الفضة والكيتوزان النانوية المحملة بالسبيراميسين على داء التوكسوبلازما | Authors | Hanaa Kamil Hamad | Issue Date | 2018 |
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