Clinical Significance of CYP-2D6*4 Polymorphism in Patients with Hepatocellular Carcinoma
Rawan Mahmoud Mohamed;
Abstract
H
epatocellular carcinoma (HCC) is the sixth most common cancer worldwide. Chronic HBV and HCV were proved to play important role in HCC etiology. In Egypt, the rates of HCV are among the highest in the world with a prevalence rate up to 20%.
However, not all individuals infected with HCV associated cirrhosis develop HCC. Other risk factors including environmental and genetic factors may be implicated in HCC development. Several studies reported that CYP450 genes are associated with cancer susceptibility. Among the CYP450 enzymes, CYP2D6 is perhaps the most extensively polymorphically expressed drug metabolizing enzyme and its polymorphism has a high clinical importance.
epatocellular carcinoma (HCC) is the sixth most common cancer worldwide. Chronic HBV and HCV were proved to play important role in HCC etiology. In Egypt, the rates of HCV are among the highest in the world with a prevalence rate up to 20%.
However, not all individuals infected with HCV associated cirrhosis develop HCC. Other risk factors including environmental and genetic factors may be implicated in HCC development. Several studies reported that CYP450 genes are associated with cancer susceptibility. Among the CYP450 enzymes, CYP2D6 is perhaps the most extensively polymorphically expressed drug metabolizing enzyme and its polymorphism has a high clinical importance.
Other data
| Title | Clinical Significance of CYP-2D6*4 Polymorphism in Patients with Hepatocellular Carcinoma | Other Titles | الأهميه الاكلينيكيه للتعدديه الشكليه لجين 2D6*4 -CYP وسرطان الكبد | Authors | Rawan Mahmoud Mohamed | Issue Date | 2018 |
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