Role of microRNA-133 in rats with diabetic cardiovascular complications

Abstract

Over recent decades, diabetes mellitus has become one of the major healthcare problems worldwide (Zang et al., 2017).Cardiovascular disease is a major cause of mortality in diabetes mellitus type 1 (T1DM) (Lee et al., 2015). Recent studies have started to unveil an unexpected and powerful role of microRNAs in numerous forms of diseases (Zampetaki et al., 2016). miRNAs play a remarkable role in the pathogenesis of diabetes mellitus type 1 and its associated cardiovascular complications by regulating multiple genes expression (Chavali et al., 2014). MiR-133a is the most abundant microRNAs in the heart and has been reported to regulate cardiac ion channels (Hedley et al., 2014). Several studies have demonstrated the crucial role of miR-133 in different cardiovascular diseases (Rawal et al., 2014). It was also found that miR-133a, induced by hyperglycemia, leads to beta-cell dysfunction and suppression of insulin biosynthesis (Fred et al., 2010). Mesenchymal stem cells have been envisioned as a promising tool for T1D treatment few years ago (Ezquer et al., 2014). This study was carried out at Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University (2016-2018) in collaboration with physiology department, Faculty of Medicine, Ain Shams University and the biochemistry &molecular biology unit -Cairo University. The study was approved by Research