(Evaluation of the effect of Insulin resistance on Sustained treatment response with direct Oral antiviral drugs(DAA) in Egyptian patients that have relapsed after treatment of chronic viral hepatitis (C

Abstract

Thisstudywasconductedon50subjectswhowereclassifiedinto25patientswhowerenonresponderstotreatmentandachievedSustainedVirologicalResponse(SVR)at12weeksonretreatmentand25patientswhowerenonresponderstotreatmentandalsofailedtoattainSustainedVirologicalResponse(SVR)at12weeksonretreatment. Allsubjectswereevaluatedatthebeginningofthestudyand6monthslaterby: InsulinresistancewascalculatedthroughtheHOMAmethodasfollows: HOMA=fastingseruminsulin(µu/ml)Xserumglucose(mmol/dL)/22.5. PatientswerecategorizedasinsulinresistantifHOMAwasgreaterthan2anddiabetesifgreaterthan4. PCRforallpatientswithchronichepatitisCandotherliverfunctiontestsweredone. Theprevalenceofinsulinresistanceissignificantlydifferentinthetwogroups.In chronic hepatitis C with failure on retreatment G2 insulin resistance increased from 5 cases (20%) to 11 cases (44%), and the other 5 cases of them