A Cross Talk between Ursolic Acid and Possible Fertility Disorders Induced by Metabolic Syndrome in Experimental Male Rats

Abstract

is study tried to investigate the effect of ursolic acid on possible fertility disorders induced by metabolic syndrome in experimental male Wistar rats. It was performed on 84 male Wistar rats allocated into six main groups (each group consists of 14 rats): - 1- Group I (Control group, C): Rats in this group were fed regular diet. 2- Group II (CL): Rats in this group were fed the same diet as in group I and received ursolic acid in a dose of 5mg/Kg daily by oral gavage for 8 weeks. 3- Group III (CH): Rats in this group were fed the same diet as in group I and received ursolic acid in a dose of 16mg/Kg daily by oral gavage for 8 weeks. 4-Group IV (Metabolic syndrome-induced group, Met.S): Rats in this group were fed high fat high fructose – enriched diet for 8 weeks for induction of metabolic syndrome. 5- Group V (Metabolic syndrome-induced group and received low dose of ursolic acid, Met.S.L): Rats in this group were fed the same diet as in group IV and received ursolic acid in a dose of 5mg/Kg daily by oral gavage for 8 weeks. 6- Group VI (Metabolic syndrome-induced group and received high dose of ursolic acid, Met.S.H): Rats in this group were fed the same diet as in group IV and received T