Studies on the construction of some heterocyclic systems of synthetic and biological importance

Abstract

The nitrogen containing heterocyclic compounds are used extensively as important synthons in organic synthesis. Also they have wide spread potential biological activities in medicinal and pesticide chemistry. The original work of this thesis can be classified into three parts: Part (I): Synthesis and spectroscopic characterization of some novel pyazoloquinoline, pyrazolyltetrazine and thiazolidinone derivatives The key starting materials for these syntheses were obtained from the reactions of two aldehydes namely 2- chloroquinoline-3-carboxaldehyde 1 and 1,3-diphenylpyrazole- 4-carboxaldehyde 2 with carbothiohydrazide and malonohydrazide. Thus, when the quinolinealdehyde 1 was allowed to react with thiocarbohydrazide and/or malonohydrazide in different ratios, bis-formyl quinolinylcarbothiohydrazide 3 and/or malonohydrazide 4 derivatives were isolated, respectively, as the sole products