Effect of lFetal Membranes and Calciu1n Channels on Basal and Stimulated Uterine Contractions

Abstract

The fetal membarnes are interposd between the fetal compartment and maternal compartment. Thus, they• are ideally positioned to regulate signals for initiation of labour. I The contractions of myometrial smooth muscle cells are I dependent on the . action potentials, so, the voltage-dependent calcium channels (VDCCs) play a critical role in the regulation of uterine contractility. I The aim of the present study was to find out the effect of fetal

membarnes on uterine contractility (basal and stimulated) of non pregnant and pregnant rats, and 2) the effect of calcium channels I on uterine contractility (basal and stimulated). of non pregnant and pregnant rats. I Uterine horns were obtained from non pregnant and pregnant I • adult female rats. Each preparations was mounted in 100 ml isolated organ bath in Ringer;s-lock solution at temperature 37 °C I and pH 7.4 and aerated with oxygen. Uterine contractions were

recorded using two channels oscillograph with isotonic transducer

Fe 117.