Paraoxonase 1 in Premature Graying of Hair
Azza Essam El-Din Lotfy El-Azhary;
Abstract
Several mechanisms are involved in the pathogenesis of premature canities ending with melanocyte depletion or malfunction. Paraoxonase-1 enzyme (PON1) has been hypothesized to be the most specific intracellular antioxidative enzyme related to oxidative stress in tissues and found decreased in a diversity of diseases.
Aim of the work: Assessment of PON1 mRNA in both gray and apparently normal hair follicles, in subjects with premature canities compared to normal controls.
Subjects and methods: Sixty volunteers, under the age of 25 years were included. Thirty with premature canities (group A), and thirty normal individual served as controls (group B). Quantitative assessment of PON1 mRNA was done in hair follicles obtained from both groups, using Real Time Polymerase Chain Reaction (RT-PCR).
Results: Direct correlation was found between severity of canities and the longer disease duration, with more sever condition affecting males group. Most patients with premature canities had positive family history. Expression of PON1 mRNA was lower in gray hair of patients with premature canities than in control group. Expression of PON1 mRNA was lower in gray hair than black hair in the same patient with premature canities.
Conclusion: Lower PON1 mRNA expression in gray hairs compared to black hairs of either patients or controls. This highlights the role of PON-1 enzyme as a possible factor in the pathogenesis of premature graying of hair, providing a possible target for further studies on canities prevention and reversal.
Aim of the work: Assessment of PON1 mRNA in both gray and apparently normal hair follicles, in subjects with premature canities compared to normal controls.
Subjects and methods: Sixty volunteers, under the age of 25 years were included. Thirty with premature canities (group A), and thirty normal individual served as controls (group B). Quantitative assessment of PON1 mRNA was done in hair follicles obtained from both groups, using Real Time Polymerase Chain Reaction (RT-PCR).
Results: Direct correlation was found between severity of canities and the longer disease duration, with more sever condition affecting males group. Most patients with premature canities had positive family history. Expression of PON1 mRNA was lower in gray hair of patients with premature canities than in control group. Expression of PON1 mRNA was lower in gray hair than black hair in the same patient with premature canities.
Conclusion: Lower PON1 mRNA expression in gray hairs compared to black hairs of either patients or controls. This highlights the role of PON-1 enzyme as a possible factor in the pathogenesis of premature graying of hair, providing a possible target for further studies on canities prevention and reversal.
Other data
| Title | Paraoxonase 1 in Premature Graying of Hair | Other Titles | قياس البارا أوكسينيز فى حالات الشـيب المبكر | Authors | Azza Essam El-Din Lotfy El-Azhary | Issue Date | 2018 |
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