Correlation Between Timing Of Wounds And The Level Of Soluble Intereellular Adhesion Molecule Type I (sICAM-I) In Traumatized Individuals
Mamdouh Kamal Labib;
Abstract
Cytokines are important in the control of wound healing. Many cytokines could be useful for the determination of wound age. The most important of these cytokines are the rowthfactors, and adhesion molecules.
The adhesion molecules identified in recent years can help to improve the diagnosis of the wound age, especially of injuries with a short survival time. The most important in this group is the intercellular adhesion molecule type-1, which is either a transmembrane protein (miCAM-1) or soluble (siCAM-1 ). •
The present study was conducted to correlate between the level of the soluble intercellular adhesion molecule type-1 (siCAM-1) and the timing of wounds in traumatized individuals.
The patients' group of the current work were divided, according to the degree of injury severity score, into three groups, mild, moderate and severe trauma groups, each group consisted of ten patients. Each group is further subdivided, according to sampling time, into three subgroups, within the 1st 24 hours of admission, on the third day, and on the fifth day of admission, while the control group consisted of six persons.
In the present study, the majority of victims were males (73.33%), 40% of patients were injured due to motor car accident, 30% due to falling from a height, 16.66% due to slipping on the ground, and sharp objects were the cause of injury in 13.33% of all the patients. The mean injury severity score of all patients was 17 06
The level of siCAM-1 was measured in plasma using the ELISA technique and was estimated in relation to the time passed since infliction of injury on the 1'1day of admission, on the 3'd day and on the 5tl1 day. A significant increase was noticed in all subgroups when compared with the control group. A characteristic pattern of siCAM-1 variation with the timing of wounds was at its max1mum level on the 3'd day post-trauma and then decreases towards its normal leveL
A number of factors was also compared with the siCAM-1 level and these included the sex of the studied individuals, the nature of injury, the associated severe head injuries, and the combining bone affection with the soft tissue injuries. There was no significant difference between both males and
I females concerning siCAM-1 level in all subgroups.
I
The adhesion molecules identified in recent years can help to improve the diagnosis of the wound age, especially of injuries with a short survival time. The most important in this group is the intercellular adhesion molecule type-1, which is either a transmembrane protein (miCAM-1) or soluble (siCAM-1 ). •
The present study was conducted to correlate between the level of the soluble intercellular adhesion molecule type-1 (siCAM-1) and the timing of wounds in traumatized individuals.
The patients' group of the current work were divided, according to the degree of injury severity score, into three groups, mild, moderate and severe trauma groups, each group consisted of ten patients. Each group is further subdivided, according to sampling time, into three subgroups, within the 1st 24 hours of admission, on the third day, and on the fifth day of admission, while the control group consisted of six persons.
In the present study, the majority of victims were males (73.33%), 40% of patients were injured due to motor car accident, 30% due to falling from a height, 16.66% due to slipping on the ground, and sharp objects were the cause of injury in 13.33% of all the patients. The mean injury severity score of all patients was 17 06
The level of siCAM-1 was measured in plasma using the ELISA technique and was estimated in relation to the time passed since infliction of injury on the 1'1day of admission, on the 3'd day and on the 5tl1 day. A significant increase was noticed in all subgroups when compared with the control group. A characteristic pattern of siCAM-1 variation with the timing of wounds was at its max1mum level on the 3'd day post-trauma and then decreases towards its normal leveL
A number of factors was also compared with the siCAM-1 level and these included the sex of the studied individuals, the nature of injury, the associated severe head injuries, and the combining bone affection with the soft tissue injuries. There was no significant difference between both males and
I females concerning siCAM-1 level in all subgroups.
I
Other data
| Title | Correlation Between Timing Of Wounds And The Level Of Soluble Intereellular Adhesion Molecule Type I (sICAM-I) In Traumatized Individuals | Other Titles | العلاقة بين توقيت الجروح ومستوى جزئ الالتصاق الذائب بين الخلايا (نوع 1) فى حالات الاصابة | Authors | Mamdouh Kamal Labib | Issue Date | 2002 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.