Urinary Nephrin as a biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus

Abstract

Our study was a cross sectional study aimed to assess the role of urinary nephrin as an early biomarker for diabetic nephropathy in patients with type 2 diabetes mellitus. We measured urinary nephrin in 75 patients with type 2 DM, patients were divided according to albumin/ creatinine ratio into 3 groups (25 normoalbuminuric patients, 25 microalbuminuric patients, 25 macroalbuminuric patients) and they were compared to 15 healthy control subjects. We compared those three groups (normoalbuminuric, microalbuminuric and macroalbuminuric groups) as regard demographic data, laboratory results and clinical parameters. We excluded patients with other causes of proteinuria or podoctypathy rather than diabetic nephropathy.