Synergistic Role ofDoxorubicin Hydrochloride and Moringa OleiferaTherapy on Benzene Induced Acute Myeloid Leukemia in rats: Histological and Immunological study.

Abstract

Cancer is a broad group of various diseases involving unregulated abnormal cell growth, develops in almost any organ or tissue. Leukemia, one of the most common forms of cancer in infants and adults, is a malignant clonal disorder characterized by alterations and low production of healthy hematopoietic cells. This alteration inhibits differentiation of cells and induces proliferation and accumulation of immature ones. Generally, in cancer, the bone marrow microenvironment becomes immunosuppressive which is caused by a limitation in proinflammatory cytokine production, inhibition of activated immune cells, and expansion of immunosuppressive cell types such as myeloid-derived suppressor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that regulate immune responses in healthy individuals and in the