Vardenafil versus Tamsulosin as a Medical Expulsive Therapy for Distal Ureteral Stones

Abstract

Follow-up would be performed every week by asking the patient about stone passage, time of stone passage, attacks of renal colic, analgesic use and side-effects of the drugs. Radiological assessment would be done every week with plain KUB. The patients would be followed-up until stone passage which would be confirmed by plain KUB, non-contrast spiral CT or at the end of the study period (4 weeks). In this study, we found that the stone expulsion rate was non significantly higher in vardenafil group compared with tamsulosin group that the expulsion rate with vardenafil was 76.0% while with tamsulosin was 72.0 %, and we found the mean of stone expulsion time was non significantly shorter in vardenafil group 9.95 days than tamsulosin group 11.28 day. Also, both drugs were safe with few side effects as headache, dizziness, orthostatic hypotenion and retrograde ejaculation. Keywords: G-Protein-Coupled Receptor - Inositol Trisphosphate - Vardenafil