Effect of Zinc on Appetite and Growth in Primary Malnourished Egyptian Children

Abstract

inc (Zn) is an essential trace mineral necessary for the proper functioning of multiple aspects of metabolism. It is present in numerous metalloenzymes, including major enzymeclasses. Zinc is the most universal of all trace elements involved in human metabolism. It is required for the normal structure and function of Zn containing enzymes, including those involved in gene expression, cell division, apoptosis, and synaptic signaling. Body weight regulation is based on the ability of the brain, particularly the hypothalamus, to integrate behavioral, endocrine, and autonomic responses via afferent and efferent pathways from and to the brainstem and peripheral organs. Leptin is a hormone made by fat cells which regulates the amount of fat stored in the body Leptin regulates the amount of fat stored in the body by adjusting both the sensation of hunger, and adjusting energy expenditures. Hunger is inhibited (satiety) when the amount of fat stored reaches a certain level. Leptin is then secreted and circulates through the body, eventually activating leptin receptors in the arcuate nucleus of the hypothalamus. Energy expenditure is increased both by the signal to the brain, and directly via leptin receptors on peripheral targets. The effect of