Red blood Cell Alloantibodies in Healthy Egyptian Blood Donors

Abstract

Alloantibodies are antibodies that are produced in response to foreign antigens; the main stimuli responsible for erythrocyte alloantibodies in healthy adult donors are previous pregnancies and transfusions. We aimed in this study to screen healthy Egyptian blood donors for the presence of red blood cells alloantibodies in a trial to prevent complications of blood transfusion. other secondary possible outcomes are to reveal the differential frequency of these alloantibodies among donors with previous blood transfusion, multiple pregnancies, and in relation to gender. This study was carried out on 200 healthy Egyptian blood donors attending Ain Shams University Hospitals Blood Banks. Data were collected for gender, age, frequent donation or first time to donate, history of previous blood transfusion, number of pregnancies and mode of delivery (in female donors) and history previous surgery. Exclusion criteria were history of hepatitis or other viral infection, history of diabetes mellitus and hypertension.