Multi variant analysis of patients with immune thrombocytopenia with paradox of thrombosis

Abstract

Immune thrombocytopenia is defined as isolated thrombocytopenia in the absence of other causes of thrombocytopenia, diagnosed by exclusion. It is characterized by decreased platelets count <100×109/L of blood resulting from auto antibody mediated peripheral platelet destruction and suboptimal platelet production. Despite thrombocytopenia, venous and arterial thrombosis cases have been reported in ITP patients. A slightly higher risk of venous thrombosis (maximum of twice the control population) was consistently found in ITP patients who were not treated with TPO-RA. No significant increase of arterial thrombosis risk was apparent. However, age, splenectomy, and personal risk factors may put some ITP patients at a particularly higher risk of venous and arterial thrombosis (up to 3-4 times higher than the average control subject). The aim of this study was to assess the thrombotic complications in immune thrombocytopenic purpura and to identify the possible risk factors. To fulfill this task 52 patients with primary immune thrombocytopenia were selected from Ain Shams University Department of Internal Medicine Clinical Hematology and Oncology Division outpatient clinic, Cairo, Egypt in the period from January