Assessment of CYP1A1 (MspI) Gene Polymorphism in Patients with Chronic Obstructive Pulmonary Disease

Abstract

C hronic obstructive pulmonary disease (COPD) is a group of progressive, debilitating respiratory conditions, including emphysema and chronic bronchitis, characterized by difficult breathing, lung airflow limitations, cough, and other symptoms. COPD is expected to be the third leading cause of worldwide mortality and the fifth leading cause of morbidity by the year 2020. Almost by definition, tobacco use is by far the most important risk factor for COPD. However, not all heavy smokers develop COPD and there has been considerable interest in other risk factors. Dusty occupational environments are well established risks. Childhood respiratory illnesses may render some people susceptible to tobacco-induced lung damage. All of these influences are minor compared to that of smoking and none satisfactorily explains the differences between smokers who develop COPD and those who do not, suggesting the influence of genetic factors on COPD susceptibility.